Quantcast
Follow us On YouTube Follow us On FaceBook



or
Search Language
Browse
Medical Animations
Medical Animation Titles
Custom Legal Animations
Anatomical Models
Patient Health Articles
Custom Interactive
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Diseases & Conditions
Cells & Tissues
Diagnostics & Surgery
Cardiovascular System
Digestive System
Integumentary System
Nervous System
Reproductive System
Respiratory System
Back and Spine
Foot and Ankle
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Cancer
Cardiology
Dentistry
Editorial
Neurology/Neurosurgery
Ob/Gyn
Orthopedics
Pediatrics
Account
Administrator Login
The Doe Report Medical Reference Library
Print this article
Pelvic Inflammatory Disease

Pelvic Inflammatory Disease Loading image. Please wait...

Aside from AIDS, the most common and serious complication of sexually transmitted diseases (STDs) among women is pelvic inflammatory disease (PID), an infection of the upper genital tract. PID can affect the uterus, ovaries, fallopian tubes, or other related structures. Untreated, PID causes scarring and can lead to infertility, tubal pregnancy, chronic pelvic pain, and other serious consequences. Each year in the United States, more than 1 million women experience an episode of acute PID, with the rate of infection highest among teenagers. More than 100,000 women become infertile each year as a result of PID, and a large proportion of the 70,000 ectopic (tubal) pregnancies occurring every year are due to the consequences of PID. In 1997 alone, an estimated $7 billion was spent on PID and its complications.Loading image. Please wait...

Cause
PID occurs when disease-causing organisms migrate upward from the urethra and cervix into the upper genital tract. Many different organisms can cause PID, but most cases are associated with gonorrhea and genital chlamydial infections, two very common STDs. Scientists have found that bacteria normally present in small numbers in the vagina and cervix also may play a role.

Investigators are learning more about how these organisms cause PID. The gonococcus, Neisseria gonorrhea, probably travels to the fallopian tubes, where it causes sloughing (casting out) of some cells and invades others. Researchers think it multiplies within and beneath these cells. The infection then may spread to other organs, resulting in more inflammation and scarring.

Chlamydia trachomatis and other bacteria may behave in a similar manner. Researchers do not know how other bacteria that normally inhabit the vagina (e.g., organisms such as Gardnerella vaginalis and Bacteroides) gain entrance into the upper genital tract. The cervical mucus plug and secretions may help prevent the spread of microorganisms to the upper genital tract, but it may be less effective during ovulation and menses. In addition, the gonococcus may gain access more easily during menses, if menstrual blood flows backward from the uterus into the fallopian tubes, carrying the organisms with it. This may explain why symptoms of PID caused by gonorrhea often begin immediately after menstruation as opposed to any other time during the menstrual cycle. It is noteworthy that the co-incidence of menses and chlamydial infection is not a prominent feature of chlamydial PID.

Symptoms
The major symptoms of PID are lower abdominal pain and abnormal vaginal discharge. Other symptoms such as fever, pain in the right upper abdomen, painful intercourse, and irregular menstrual bleeding can occur as well. PID, particularly when caused by chlamydial infection, may produce only minor symptoms or no symptoms at all, even though it can seriously damage the reproductive organs.

Risk Factors for PID

  • Women with STDs - especially gonorrhea and chlamydial infection - are at greater risk of developing PID; a prior episode of PID increases the risk of another episode because the body's defenses are often damaged during the initial bout of upper genital tract infection.
  • Sexually active teenagers are more likely to develop PID than are older women.
  • The more sexual partners a woman has, the greater her risk of developing PID.

Recent data indicate that women who douche once or twice a month may be more likely to have PID than those who douche less than once a month. Douching may push bacteria into the upper genital tract. Douching also may ease discharge caused by an infection, so the woman delays seeking health care.

Diagnosis
PID can be difficult to diagnose. If symptoms such as lower abdominal pain are present, the doctor will perform a physical exam to determine the nature and location of the pain. The doctor also should check the patient for fever, abnormal vaginal or cervical discharge, and evidence of cervical chlamydial infection or gonorrhea. If the findings of this exam suggest that PID is likely, current guidelines advise doctors to begin treatment.

If more information is necessary, the doctor may order other tests, such as a sonogram, endometrial biopsy, or laparoscopy to distinguish between PID and other serious problems that may mimic PID. Laparoscopy is a surgical procedure in which a tiny, flexible tube with a lighted end is inserted through a small incision just below the navel. This procedure allows the doctor to view the internal abdominal and pelvic organs, as well as take specimens for cultures or microscopic studies, if necessary.

Treatment
Because culture of specimens from the upper genital tract are difficult to obtain and because multiple organisms may be responsible for an episode of PID, especially if it is not the first one, the doctor will prescribe at least two antibiotics that are effective against a wide range of infectious agents. The symptoms may go away before the infection is cured. Even if symptoms do go away, patients should finish taking all of the medicine. Patients should be re-evaluated by their physicians two to three days after treatment is begun to be sure the antibiotics are working to cure the infection.

About one-fourth of women with suspected PID must be hospitalized. The doctor may recommend this if the patient is severely ill; if she cannot take oral medication and needs intravenous antibiotics; if she is pregnant or is an adolescent; if the diagnosis is uncertain and may include an abdominal emergency such as appendicitis; or if she is infected with HIV (human immunodeficiency virus, the virus that causes AIDS).

Many women with PID have sex partners who have no symptoms, although their sex partners may be infected with organisms that can cause PID. Because of the risk of reinfection, however, sex partners should be treated even if they do not have symptoms.

Consequences of PID
Women with recurrent episodes of PID are more likely than women with a single episode to suffer scarring of the tubes that leads to infertility, tubal pregnancy, or chronic pelvic pain. Infertility occurs in approximately 20 percent of women who have had PID.

Most women with tubal infertility, however, never have had symptoms of PID. Organisms such as C. trachomatis can silently invade the fallopian tubes and cause scarring, which blocks the normal passage of eggs into the uterus.

A women who has had PID has a six-to-tenfold increased risk of tubal pregnancy, in which the egg can become fertilized but cannot pass into the uterus to grow. Instead, the egg usually attaches in the fallopian tube, which connects the ovary to the uterus. The fertilized egg cannot grow normally in the fallopian tube. This type of pregnancy is life-threatening to the mother, and almost always fatal to her fetus. It is the leading cause of pregnancy-related death in African-American women.

In addition, untreated PID can cause chronic pelvic pain and scarring in about 20 percent of patients. These conditions are difficult to treat but are sometimes improved with surgery.

Another complication of PID is the risk of repeated attacks of PID. As many as one-third of women who have had PID will have the disease at least one more time. With each episode of reinfection, the risk of infertility is increased.

Prevention
Women can play an active role in protecting themselves from PID by taking the following steps:

  • Signs of discharge with odor or bleeding between cycles could mean infection. Early treatment may prevent the development of PID.
  • If used correctly and consistently, male latex condoms will prevent transmission of gonorrhea and partially protect against chlamydial infection.

Research
Although much has been learned about the biology of the microbes that cause PID and the ways in which they damage the body, there is still much to learn. Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID) are studying the effects of antibiotics, hormones, and substances that boost the immune system. These studies may lead to insights about how to prevent infertility or other complications of PID. Topical microbicides and vaccines to prevent gonorrhea and chlamydial infection also are being developed. Clinical trials are in progress to test a suppository containing lactobacilli - the normal bacteria found in the vaginas of healthy women. These bacteria colonize the vagina and may be associated with reduced risk of gonorrhea and bacterial vaginosis, both of which can cause PID.

Rapid, inexpensive, easy-to-use diagnostic tests are being developed to detect chlamydial infection and gonorrhea. A recent study conducted by NIAID-funded researchers demonstrated that screening and treating women who unknowingly had chlamydial infection reduced cases of PID by more than 60 percent. Meanwhile, researchers continue to search for better ways to detect PID itself, particularly in women with "silent" or asymptomatic PID.

Source: National Institute of Allergy and Infectious Diseases
July 1998.
Last Updated June 6, 2003



Medical/Legal Disclaimer
Copyright © 2003 Nucleus Medical Art, Inc. All Rights Reserved.
Related Medical Demonstrative Evidence - click thumbnail to review.
Urinary Tract Infection
Urinary Tract Infection -
Medical Animation
Add to my lightbox
Find More Like This
Understanding Ovarian Cancer
Understanding Ovarian Cancer -
Medical Animation
Add to my lightbox
Find More Like This
Ectopic Pregnancy
Ectopic Pregnancy -
Medical Exhibit
Add to my lightbox
Find More Like This
Ruptured Membranes and Spread of Infection
Ruptured Membranes and Spread of Infection -
Medical Exhibit
Add to my lightbox
Find More Like This
Triplets: Premature Rupture of the Fetal Membrane with Progressive Intrauterine Spread of Infection
Triplets: Premature Rupture of the Fetal Membrane with Progressive Intrauterine Spread of Infection -
Medical Exhibit
Add to my lightbox
Find More Like This
Cervical Cancer Symptoms
Cervical Cancer Symptoms -
Medical Animation
Add to my lightbox
Find More Like This
Tubal Ligation Surgery
Tubal Ligation Surgery -
Medical Illustration
Add to my lightbox
Find More Like This
Meningococcal Disease: Progression of Infection
Meningococcal Disease: Progression of Infection -
Medical Exhibit
Add to my lightbox
Find More Like This
Female Reproductive System, Anterior Cut-away View
Female Reproductive System, Anterior Cut-away View -
Medical Illustration
Add to my lightbox
Find More Like This
Inflammation and Adhesions of the Pelvis with Obstruction of the Fallopian Tubes
Inflammation and Adhesions of the Pelvis with Obstruction of the Fallopian Tubes -
Medical Exhibit
Add to my lightbox
Find More Like This
Catheter-Related Bloodstream Infection
Catheter-Related Bloodstream Infection -
Medical Animation
Add to my lightbox
Find More Like This
Urinary Tract Infection (UTI)
Urinary Tract Infection (UTI) -
Medical Animation
Add to my lightbox
Find More Like This
How do I find a personal injury lawyer in my local area?
Find a personal injury lawyer in your local area using LEGALpointer™, a national directory of U.S. attorneys specializing in personal injury, medical malpractice, workers' compensation, medical product liability and other medical legal issues. Or, click on one of the following to see attorneys in your area: Alabama (AL), Alaska (AK), Arizona (AZ), Arkansas (AR), California (CA), Colorado (CO), Connecticut (CT), Delaware (DE), Washington D.C. (DC), Florida (FL), Georgia (GA), Hawaii (HI), Idaho (ID), Illinois (IL), Indiana (IN), Iowa (IA), Kansas (KS), Kentucky (KY), Louisiana (LA), Maine (ME), Maryland (MD), Massachussets (MA), Michigan (MI), (MN), Mississippi (MS), (MO), Montana (MT), North Carolina (NC), North Dakota (ND), Nebraska (NE), Nevada (NV), New Hampshire (NH), New Jersey (NJ), New Mexico (NM), New York (NY), Ohio (OH), Oklahoma (OK), Oregon (OR), Pennsylvania (PA), Puerto Rico (PR), Rhode Island (RI), South Carolina (SC), South Dakota (SD), Tennessee (TN), Texas (TX), Utah (UT), Virginia (VA), Virgin Islands (VI), Vermont (VT), Washington (WA), West Virginia (WV), Wisconsin (WI).












Awards | Resources | Articles | Become an Affiliate | Free Medical Images | Pregnancy Videos
Credits | Jobs | Help | Medical Legal Blog | Find a Lawyer | Hospital Marketing